Video bubuk OEA (111-58-0)

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Bubuk OEA Specifications

Nama:	Oleoylethanolamide (OEA)
CAS:	111-58-0
Kemurnian	98%
Formula molekul:	C
Berat molekul:	X
Titik Meleleh:	59 – 60 ° C
Nama kimia:	N-Oleoyletanolamida
Sinonim:	N-Oleoylethanolamine, N- (Hydroxyethyl) oleamide, N- (cis-9-Octadecenoyl) ethanolamine, OEA
Kunci InChI:	SUHOQUVVVLNYQR-MRVPVSSYSA-N
Setengah hidup:	N / A
Kelarutan:	Larut dalam DMSO, Methanol, Air
Kondisi penyimpanan:	0 - 4 C untuk jangka pendek (hari ke minggu), atau -20 C untuk jangka panjang (bulan)
Aplikasi:	Oleoylethanolamide (OEA) adalah metabolit alami yang dibuat dalam jumlah kecil di usus kecil Anda. OEA membantu mengatur rasa lapar, berat badan, lemak tubuh dan kolesterol dengan mengikat pada reseptor yang dikenal sebagai PPAR-Alpha (Peroxisome proliferator-activated receptor alpha).
Penampilan:	Bubuk putih

Oleoiletanolamida (OEA) (111-58-0) Spektrum NMR

Oleoylethanolamide (OEA) (111-58-0) - Spektrum NMR

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Apa itu Oleoylethanolamide (OEA) CAS 111-58-0?

Oleoylethanolamine (OEA) adalah lipid etanolamida yang terjadi secara alami dan reseptor nukleaktif teraktivasi proliferator peroksisom reseptor-α (PPAR-α). Ini diproduksi di usus kecil dan menghambat asupan makanan melalui aktivasi PPAR-α. OEA juga mengaktifkan GPR119, lipid bioaktif dengan efek hipofagik dan anti-obesitas.

Manfaat Oleoylethanolamide (OEA) CAS 111-58-0

Oleoylethanolamide (OEA) adalah metabolit alami yang dibuat dalam jumlah kecil di usus kecil Anda. OEA membantu mengatur rasa lapar, berat badan, lemak tubuh, dan kolesterol dengan mengikat reseptor yang dikenal sebagai PPAR-Alpha (Peroxisome proliferator-activated receptor alpha). Intinya, OEA meningkatkan metabolisme lemak tubuh dan memberitahu otak Anda bahwa Anda sudah kenyang dan saatnya berhenti makan. OEA juga diketahui meningkatkan pengeluaran kalori yang tidak berhubungan dengan olahraga.

Oleoylethanolamide (OEA) CAS 111-58-0 Mekanisme aksi?

Oleoyletanolamida (OEA) disintesis dan dimobilisasi di usus kecil proksimal dari asam oleat yang berasal dari makanan, seperti minyak zaitun. Diet tinggi lemak dapat menghambat produksi OEA di usus. OEA mengurangi asupan makanan dengan mengaktifkan sirkuit otak homeostatis oksitosin dan histamin serta jalur dopamin hedonis. Terdapat bukti bahwa OEA juga dapat melemahkan sinyal hedonik cannabinoid receptor 1 (CB1R), yang aktivasinya berhubungan dengan peningkatan asupan makanan. OEA mengurangi transportasi lipid ke adiposit untuk menurunkan massa lemak. Penjelasan lebih lanjut mengenai dampak OEA terhadap pangan asupan dan metabolisme lipid akan membantu penentuan mekanisme fisiologis yang dapat ditargetkan untuk mengembangkan terapi obesitas yang lebih efektif.

Oleoyletanolamida (OEA) adalah agonis reseptor-α yang diaktifkan proliferator peroksisom (PPAR-α). N-Oleoylethanolamide menghasilkan sinyal usus yang menstimulasi aktivitas dopamin sentral yang membentuk hubungan antara pengontrol kalori-homeostatik dan hedonik-homeostatik. Oleoyletanolamida telah terlibat sebagai mekanisme molekuler yang terkait dengan keberhasilan bypass lambung. N-Oleoyletanolamida adalah agonis GPR55 selektif.

Oleoylethanolamide (OEA) CAS 111-58-0 Aplikasi

Oleoylethanolamide (OEA) bekerja untuk mengaktifkan sesuatu yang disebut PPAR dan secara bersamaan meningkatkan pembakaran lemak dan mengurangi penyimpanan lemak. Saat Anda makan, tingkat OEA meningkat dan nafsu makan Anda menurun ketika saraf sensorik yang terhubung ke otak Anda mengatakan bahwa Anda kenyang. PPAR-α adalah sekelompok reseptor inti yang diaktivasi ligan yang terlibat dalam ekspresi gen metabolisme lipid dan jalur energi homeostasis.

Bubuk OEA dijual(Di mana dapat membeli bubuk Oleoylethanolamide (OEA) dalam jumlah besar)

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Kami adalah pemasok bubuk Oleoylethanolamide (OEA) profesional selama beberapa tahun, kami menyediakan produk dengan daya saing harga, dan produk kami memiliki kualitas terbaik dan menjalani pengujian yang ketat dan independen untuk memastikan aman untuk dikonsumsi di seluruh dunia.

Referensi

Gaetani S, Oveisi F, Piomelli D (2003). "Modulasi pola makan pada tikus oleh mediator lipid anoreksia oleoylethanolamine". Neuropsikofarmakologi. 28 (7): 1311–6. doi:10.1038/sj.npp.1300166. PMID 12700681.
Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D (2005). "Pengaturan asupan makanan oleh oleoylethanolamine". Sel. Mol. Life Sci. 62 (6): 708–16. doi: 10.1007 / s00018-004-4494-0. PMID 15770421.
Gaetani S, Kaye WH, Cuomo V, Piomelli D (September 2008). "Peran endocannabinoid dan analognya dalam obesitas dan gangguan makan". Makan Gangguan Berat Badan. 13 (3): e42–8. PMID 19011363.